Author Topic: Neurotransmitter imbalances caused by SSRIs and other  (Read 35499 times)

Alan19email

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Neurotransmitter imbalances caused by SSRIs and other
« on: January 31, 2010, 09:51:58 AM »
Note by EA Admin.

This topic is specifically for discussing possible neurotransmitter imbalances that may have been caused by the taking of prescription medications such as SSRIs (anti-depressants).

It would seem that it is also possible to have neurotransmitter imbalances from natural causes, whether it be from prolonged periods of depression (without medication), lifestyle factors, genetic disposition or other.

Anything relevant to either of the above should be posted here.

Originally post titled "ALAN AND HIS GABA Plus" follows.

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Hello everyone. Here is a quickie version of my experience with what is being called ejaculatory ahedonia.

In the mid 1980's I started getting flu like symptoms intermittenly. I would get the flu for a week then would recover for 3 weeks, then get the flu for 2 weeks and recover for 2 weeks, then get the flu for 3 weeks and recover for only one week, then I had flu like symptoms every day, every week, every month. Doctors could do nothing for this and simply dismissed me with; it all in your head. I would get home from work and immediately go to bed and sleep until the next morning. On Friday when I got home I would go to bed and not get out of bed until Monday morning.

My house mate at the time was a woman who was diagnosed as having diabetes and her doctor told her to use Aspartame the deadly neuro-toxin artifical sweetner instead of sugar. I would make deserts and stuff using Aspartame. My flu like symptoms started right after we started using Aspartame and I have not recovered as of 25 years later.

No doctor knew what was wrong with me and as I got to a point where I could not remember the gate code at work, and fell asleep when I drank my coffee on break, my companies medical department sent me home and found a doctor for me. He immediately put me out on disability and for the next 5 years I mostly slept or sat in front of the TV. Reruns were OK since I could not remember the ending from the first time I saw them. My new doctor put me on SSRI's, elavil, then triavil, and within a few months I started having difficulty with sex where I could not ejaculate. The doctor had me cut the SSRI pills in half and while sex returned to normal I did not have an orgasm when I ejaculated. I would want to have sex, I would want to "get off", I enjoyed all the foreplay and then when I knew I was going to 'cum' and I expected bells and whistles, I would ejaculate and not have the orgasm. I might just as well of blown my nose for all the reward I got from it.

I was already depressed from the flu like illness and the SSRI just barely took the edge off and now I could not feel the reward of sex. Trying to get a doctor to understand what I was talking about was next to impossible. I enjoyed sex and I wanted to have it. Doing sex was wonderful rewarding and satisfying recreation, and then when I knew that the reward of the past hour was about to explode in other worldy extasy, I would cum and that would be it. No orgasm.

When it was suggested to me that the SSRI's might be the cause and I realized that the doctor really did not know for sure how to help me with what we are calling CFIDS/FM, I started looking online for solutions. I read a doctor who insisted that Western medicine where they try to over power the body was wrong and that nature had the answer to help the body do what it knew how to do, I decided I would never take another of Big Pharma's poisons and that from now on it would be vitamins, supplements and nutrition.

About 7 years ago my doctor asked me to have my thyroid levels checked and while the tests showed normal, he said I had all the symptoms of low thyroid. So I started taking Raw Thyroid and immediately my orgasms returned better than ever. My flu like symptoms disappeared and I had normal health for the first time in 10 years. But after 4 months of normal energy, health and sexual function the Raw Thyroid stop working. When I doubled the dose I started having symptoms of hyperthyroidism. I was back to being exhausted all the time, hurting all over and no orgasm when I ejaculated.

I continued to try different herbs and supplements and sometimes I would have some part of orgasm but not a full blown other worldly experience with bells and whistles. Mostly there was no orgasm, I might just as well have been doing push ups.

Then a doctor suggested GABA for my CFIDS/FM, my flu like, depression and exhaustion illness. Within a few days I noticed I was starting to have orgasm again. I also felt better than I had in 25 years. Now after using the GABA for 8 weeks I have to say that my orgasm's are completely normal, rewarding and satisfying.

I'll add more as I remember details, right now I have to leave.
« Last Edit: February 23, 2010, 02:43:55 PM by EA Admin »

lostmojo

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Re: ALAN AND HIS GABA Plus
« Reply #1 on: February 03, 2010, 05:23:21 PM »
I have not tried Twinlab GABA Plus (Niacinamide 400mg, GABA 200mg, Inositol 1200mg) but I am doing a make your own type equivalent.

I have been taking 1 capsule of Now Foods GABA 500mg with B6 for 4 weeks (by itself) and can't say that I have noticed any improvement.
http://www.nowfoods.com/Products/ProductsAlphabetically/M002906.htm

In the last 2 days I have added 1 capsule of Now Foods Niacinamide (B-3) 500mg
http://www.nowfoods.com/Products/ProductsAlphabetically/M003598.htm

and I also am taking 1 metric teaspoon (2.5 grams) twice daily of pharmaceutical grade Inositol from Blackburn Distributions Ltd in the UK.

I realize these doses are different to what is in the Twinlab GABA Plus but I can always adjust them as I go along. If I were to increase the Niacinamide to 3 capsules a day and the GABA to 2 capsules a day then it would be pretty close to taking 4 Twinlab capsules a day. Interesting that Inositol has by far the largest dose of the 3 ingredients. I will report on my progress.

Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #2 on: February 05, 2010, 10:40:25 AM »
That all sounds good Lostmojo, I read an article and I believed it, but I am not a scientist and have done no research at all myself, the article said the proportions were important. Just because someone says this does not make it true, but when I have not had an orgasm for so long, and then I take GABA and I start having them, it makes me think; don't reinvent the wheel.

Some body builders take up to 2 grams of GABA, putting the powder on their tongue's through out the day. Some have suggested it is only absorbed 90 minutes after you fall asleep, and only on an empty stomach.

Anyone with acid reflux never has an empty stomach. I take Betain HCL with every meal to help me digest the food I eat. If I do not take it I get acid reflux and feel bloated all the time.

I would not mind buying some bulk GABA and seeing if putting it under my tung would give the same results.

Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #3 on: February 05, 2010, 11:25:56 AM »
I am in week 9 using GABA and my orgasm's range between 9-10 on the 1-10 scale.

A couple night ago I noticed my feet and hands were icy cold again and that is the night my rating of my orgasm dropped from 10 down to 9. I took some Thyroid Helper with Kelp and I seem to be back to normal again. Apparently it is not only the GABA levels that have to be high but my thyroid has to be working at its best as well.


Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #4 on: February 08, 2010, 10:39:04 PM »
I wanted to mention that the GABA is still working for me 100%. This is week 10 I believe.

Alan19email

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ALAN TO DANBO
« Reply #5 on: February 10, 2010, 10:02:14 PM »
danbo800 wrote: I actually havent had many good orgasms lately.  I hope I am not getting too used to teh GABA and its not as effective anymore.  I just got the twinlab product shipped and I have 3 bottles of 100 pills a bottle.  It only cost me 38 dollars with shipping so not too bad.  Maybe I will have better results after a few weeks back on this product.  Alan you mention you dont try to get off unless your body tells you.  I can sort of relate.  I actually can pretty much predict a good orgasm or bad even before I start masterbating.  If I get spontaneous erections before I start i know most of the time that ist going to be good.

ALAN: Sometimes when I listen to my body and start to have sex, my body changes its mind sort of speak, and I know if I continue to ejaculation the orgasm will not be very rewarding.

I hate that we are so limited in how much each post can contain.

Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #6 on: February 10, 2010, 10:04:53 PM »
danbo: I can relate to the good feeling GABA gives and for me it has been mostly at night sleeping or waking up in the morning. The problem with me is lately I just am never getting that feeling. It could be because i havent been taking the inositol with the niacin and gaba.

ALAN: Some people believe it is the inositol that is making the orgasm happen. I believe that all three are required.

danbo: I will see what happends the next few weeks. I have also noticed teh longer I go without masterbating it acutally feels worse.

ALAN: Me too! strange isn't it.


Alan19email

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Re: ALAN TO DANBO
« Reply #7 on: February 10, 2010, 10:06:59 PM »
danbo: Also this is a general question for anyone here. When you ejaculate does your penis pulsate for 5 to 10 seconds. Actually noticed that on a porn when a guy came that you could see the veins pulsating. I actually dont get that and I have noticed when I have had a great orgasm I get that pulsation much greater. When I get a weak non pleasurable orgasm I just sort of leak sperm out and there is just nothing behind it.

ALAN: When I was young I would shoot and hit my forehead or the wall. Now, mostly it dribbles out.

Alan19email

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Re: ALAN TO DANBO
« Reply #8 on: February 10, 2010, 10:09:14 PM »
danbo: I currently have a bad tooth ache so I have to limit some of my supplements since I am taking a lot of advil to help relieve the pain. So I have to step back a little bit from my normal routine of vitamins. I would like to take the zinc, b-complex, 3 to 4 twinlab capsules, and multi vitamin. I wish SickandTired would at least come back to post something on her progress. i know last time i heard from her she was completely back to normal. Orgasms should be more natural and its not for most of us. I should be able to just get off and feel pleasure but its a huge accomplishment if the least bit of pleasure comes.

ALAN: I think it is important to be consistent with supplements. And to listen to you body and only have sex when your body tells you it wants to.

Alan19email

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Re: ALAN TO DANBO
« Reply #9 on: February 10, 2010, 10:11:07 PM »
danbo posted: Perhaps more unusual-sounding than orgasmia is the concept of orgasms that have nothing to do with the genitalia at all. Some people can orgasm from being touched in other places on the body, such as the nipples. In this case, researchers believe that the sensations in the nipples are transmitted to the same areas of the brain that receive information from the genitals. However, people have also reported actually feeling orgasms in other parts of their bodies, including their hands and feet. Several people have even described having orgasms in limbs that were no longer there. One reason may be the layout of the cortical homunculus, a map that shows how different places of the brain's sensory and motor cortices correspond to the organs and limbs of the body. A person who feels an orgasm in a phantom foot, for example, may have experienced a remapping of the senses because the foot is located next to the genitals in the homunculus. The foot is no longer there to provide sensation, so the area for genital sensation took over the space.

ALAN: I find this extremely interesting.

searchingforcure11

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Re: ALAN TO DANBO
« Reply #10 on: February 10, 2010, 10:25:28 PM »
Ya it does kind of suck we cant even put links on there.  The moderator is over supervising that website.  More people need to come over here.  Also it is still slow for me in loading.  Ya for me its a happy time when I can just get aroused.  The thought of sex arouses me more then looking at porn.  Cuddling arouses me more then porn.  I need human interaction to feel something.  That could be the problem really.  Too much masterbation which is boring.  I hope the GABA starts working again for me.  It seemed to work for a period there and I hope I get back to that.  Just that feeling I got in the middle of the night where my feet felt all warm and tingly and I got rock hard erections which were pulsating was great.  I know when I get them sort of erections I know i am going to feel pleasure.  The problem is that I dont get that often.  Porn dont have that effect anymore for me.

Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #11 on: February 10, 2010, 10:31:20 PM »
GABA HgH releaser agent, you will find it when you look at the ingredients for most growth hormone releasers.
GABA (Gamma-aminobutyric acid) is essential for brain metabolism, and is made in the body from another amino acid, glutamic acid.
As human growth hormone is produced in the brain by the pituitary, GABA HgH releaser influences the brain environment in a positive way to facilitate the production and release of growth hormone.

The functions that GABA has in the brain are;

Decreases neuron activity
Suppresses overfiring of nerve cells
Essential for brain metabolism
Aids in proper brain functioning
Is a neurotransmitter in the central nervous system
Stimulates the pituitary gland to secrete(release) more human growth hormone
These functions give GABA the ability to enhance communication between nerve cells and lower stress related pulses in the brain.
Combined with niacinamide and inositol, GABA prevents stress related signals from reaching the inner brain.

The human body has the ability to produce sufficient GABA HgH releaser, but like all good things in life, the production of GABA is adversely affected by the most common lifestyle today that has a poor diet, little or no physical activity, stress, toxic agents in the environment and such.
It is this same lifestyle that is a major factor in the periodic lowering of the release of human growth hormone by the pituitary gland.


Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #12 on: February 10, 2010, 10:33:07 PM »
So how can we use all these properties of GABA to our benefit? GABA is relaxing, eases up stress and calms the body in the same way tranquilizers do but with no risk of addiction which makes this amino acid useful against insomnia, epilepsy and hypertension.
These same properties are the greatest benefit to HgH release from GABA, prevention of stress, optimization of the brains inner working and stimulation of the pituitary make it increasingly easy for the pituitary to release more growth hormone.

Studies have shown that its effect on the pituitary lead to an increase of up to 5 times more growth hormone in the blood when taken in amounts between 2 and 5 grams per day.
As with all growth hormone releaser products, injections are more effective than capsules but the capsules have also proven to be effective, and in our opinion easier to use at a lower cost.
If you use only GABA as a HgH releaser never go over 18 grams per day, as the effectiveness of the amino acid will not increase further, but you may well be confronted with some of the amino acid side effects like increased anxiety, tingling, changes in hearth and breath rate and numbness around the mouth.

When using amino acids as an HgH releaser it is wiser to use a combination of amino acids rather than focusing on one because introducing too great an imbalance in the amino acid levels leads to canceling out the benefits and increasing the (minor) risk of side effects.
For this reason we advise to take GABA in combination with other HgH releasing amino acids like L-Arginine, L-Ornithine, L-Lysine and glutamine before going to sleep.
In such a formula, L-Arginine and/or L-Ornithine should distinctively carry the heavy load.


Alan19email

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Re: ALAN TO DANBO
« Reply #13 on: February 10, 2010, 10:39:40 PM »
dan1121: Ya it does kind of suck we cant even put links on there.  The moderator is over supervising that website.  More people need to come over here.  Also it is still slow for me in loading.  Ya for me its a happy time when I can just get aroused.  The thought of sex arouses me more then looking at porn.  Cuddling arouses me more then porn.  I need human interaction to feel something.  That could be the problem really.  Too much masturbation which is boring. 

ALAN: If you are masturbating when bored or using it to relieve boredom I can see that could be a problem.

Dan:  I hope the GABA starts working again for me.  It seemed to work for a period there and I hope I get back to that.  Just that feeling I got in the middle of the night where my feet felt all warm and tingly and I got rock hard erections which were pulsating was great.  I know when I get them sort of erections I know i am going to feel pleasure.  The problem is that I dont get that often.  Porn dont have that effect anymore for me.

ALAN: I haven't noticed those hard on's with sexy dreams at night lately. Interesting. I posted some info about taking 2-5 grams of GABA to increase Human Growth Hormone, and they also suggest taking it with a couple other items.  Check it out.
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Alan19email

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Re: ALAN AND HIS GABA Plus
« Reply #14 on: February 10, 2010, 10:43:32 PM »
From a review of GABA:

GABA (Gamma Amino Butyric Acid), one of the most common amino acid components of HgH Releasers and does a very good job at creating a positive environment in the brain for HgH release. It also stimulates the pituitary to produce and release growth hormone. Research shows that when taken in amounts of 2 to 8 grams per day, the growth hormone level in the blood rises up to 5 times.

With Twinlab GABA Plus the dosage we would advise is 2 to 5 capsules ( max. 500 mg of GABA). Combine this with L-Arginine (3 grams), L-Lysine(1 gram) and L-Ornithine(1 gram) and you now have a potent 5.5 gram amino acid releaser that will be effective in most cases.

GABA (and all amino acids or amino acid based products for that matter) should be taken according to gender, body weight and age;

Females under 120 pounds: 2 grams a day
Females between 121 and 180 pounds: 4 grams a day
Females over 181 pounds: 6 grams a day
Age may warrant an intake bonus of 2 to 4 grams, the older you are, the more amino acids you will need.

Males under 140 pounds: 2 to 4 grams a day
Males between 141 and 200 pounds: 6 grams a day
Males over 200 pounds: 8 grams a day
Age may warrant an intake bonus of 2 to 4 grams, the older you are, the more amino acids you will need.


On dosages above 4 grams we have found that cycling the intake (take Amino Acids for 5 days and take a 2 day rest) will not lead to decreased efficacy.

Raising your GH levels by means of GABA intake is adversely influenced by negative lifestyle factors (smoking, drinking, bad eating habits, too little sleep, little or no exercise) and the absence of vitamin C in your diet. Vitamin C is needed for the adsorption of this amino acid by the digestive system.

GABA will not work for you if your pituitary gland does not produce HgH due to illness or removal, and will be effective to a lesser extent if your pituitary produces an abnormal low amount of Hgh Human growth hormone for your age.