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http://www.longecity.org/forum/topic/73159-signs-and-symptoms-of-low-nmda-activity-n-methyl-d-aspartate/

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NMDA can also enhance GABA release and releases pregnenolone and IGF-1; which can have pro-anabolic effects altogether, AND, NMDA acts as a major gonadotropic signaler, where it can massively increase testosterone and other sex hormones.

This is interesting. I remember years ago on another popular health site, that a guy started a thread on Ejaculatory Anhedonia. It became a huge mega thread, and he was finally able to cure himself by taking GABA (didn't work for me though).

What is also interesting about the above passage is it enhances the release of pregnenolone. I remember when I took pregnenolone, I would ejaculate very fast, and my penis head did become more sensitive and pleasurable. I thought pregnenolone could have been the key for me at one point, but I couldn't take it anymore because it worsened my peyronies disease.

But from the above passage, it's saying NDMA enhances GABA, pregenolone, and testosterone as well as other sex hormones. So NMDA seems like an all rounder for influencing sexual function it sounds like.
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Hey, it was just me posting, not 2 people. I will post my results here, good or bad, but only after a week or two.

The plan is to build up my stores or whatever by taking a lot of these 2 fibers over time, and then masturbate.

When I google nmda orgasm, I stumbled upon this:

https://drugs-forum.com/threads/dxm-use-and-intense-orgasms.207416/


DXM use and intense orgasms?

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SWIM is a female that occasionally enjoys recreational use of DXM. After awhile it became apparent to SWIM that a couple of days after dosing SWIM could achieve the most spectacular orgasms of her life, sometimes multiple.

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DXM is an NMDA antagonist. NMDA antagonists have been scientifically shown to be able to reverse tolerance, have antiaddictive effects, and even to prevent the development of tolerance when administered with other drugs. It also increases the concentration of Dopamine in the brain by blocking PCP-2 receptors.


I thought there might be a connection there, as FOS has been proven to increase "levels of BDNF & NMDA receptor subunits in the hippocampus" in rats. But then after googling "antagonist", it means inhibit. So DXM inhibit NMDA, so the opposite of what the fiber does.

However she does say "after awhile it became apparent to SWIM that a couple of days after dosing". So this might make sense, as the brain tries to rebalance itself out from the suppression of NMDA, by producing more NMDA or more NMDA receptors or something.

It happens with most things in the body, from what I understand. For example bodybuilding take aromotase inhibitors to restart their testosterone production. This works because the body usually makes estrogen from testosterone, and when it senses the estrogen is low, it produces more testosterone to try and boost production. I've also read, if you give people dopamine inhibitors for a long time, their brain creates more dopamine receptors to try and counter balance. It's the rebound effect.

So if DXM is a NMDA antagonist, then it's suppressing NMDA for a few days or whatever, so her brain starts to compensate by increasing NMDA receptors or trying to increase NMDA production. Once the DXM suppressing effect has worn off and stops suppressing her NMDA in the brain, she should enjoy a rebound effect of the increased NMDA or NMDA receptors in her brain for a little while.

If this is the case why she has the most intense orgasms of her life, and FOS (that fiber) can increase "levels of BDNF & NMDA receptor subunits in the hippocampus" in rats. If FOS does the same in humans, then it might be a winner for EA.

That's the NMDA theory of all this anyway.
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I hope you'll both report your results here.
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Just doing some quick research, both these fibers are said to act as prebiotics:

Inulin (Fructo-Oligosaccharide (FOS))
VitaFiber (Isomalto-oligosaccharide (IMO))

Searching the net, I cound this:

Prebiotics (FOS, GOS) given to rats lead to increased levels of BDNF & NMDA receptor subunits in the hippocampus

http://www.longecity.org/forum/topic/68440-prebiotic-feeding-elevates-hippocampal-bdnf/

"Our data therefore provide a sound basis to further investigate the utility of prebiotics in the maintenance of brain health and adjunctive treatment of neuropsychiatric disorders."


I think I'll start taking a lot of Inulin and Vitafiber as they're sweet and easy to consume. I should be able to take them several times a day if I only do those 2 and avoid the other 3.
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Hey guys. My back story is I've been suffering from EA since the age of 16 (I'm now 29).

Recently I've got a fiance, I watch much less porn, and I've dabbled in weed. However none of these has brought orgasm back, alone, or with her.

I also try to regularly take my supplement stables of liquid magnesium, zinc, and vitamin e every night. None of these have effected my orgasm.

However at 4pm today I went for a shower, and decided to rub one out, and even though I can't remember an orgasm as such when ejaculating, after the ejaculation, my penis head was so pleasurable and sensitive, and rubbing it after ejaculation caused me to urinate several times due to the pleasure, and I also remember my leg would shake a little bit. Also note I used some Rose oil I found (first time).

Anyway the only thing I had done differently, is I bought a load of different types of fiber from myprotein.com, because I wanted to try and lose some weight before my wedding, and read that eating a mixture of fiber helps suppress appetite. So I bought 5 different types of fiber, and have been consuming a lot of it yesterday and today. Also this is the first time I used Rose oil as a lubricant, though I doubt this would have had such an effect.

Now I'm not saying that fiber is the connection. But this is probably the best pleasure I had from my dick in a long time, so I wanted to post it here just in case there was something to it. For example maybe there is a link to the fiber I'm eating, to feeding the bacteria in my gut, causing them to create the right hormones or neurotransmitters or something to give my dick some pleasure; I have no idea. But I thought I'd post it just in case there could be a connection.

The fibers I bought were:

Apple Fibre
Inulin (Fructo-Oligosaccharide (FOS))
Guar Gum
VitaFiber (Isomalto-oligosaccharide (IMO))
GLUCOMANNAN (Konjac)


VitaFiber is interesting because it's sweet (60% the sweetness of sucrose), but it's low calories (practically none) like other fibers. Definitely the easiest to take. But the sweetness makes me wonder if gut bacteria can use it.

For those who are wondering, I try to take a teaspoon (5g) of each, and down it before each meal. However if you try this, fibres, especially in powder form, can swell and get stuck in your throat, so be careful.

Anyway whether there is a connection there or not, I have no idea. But I thought I'd pop back and post it. The other thing I should note, is I could literally be slowly regaining my orgasm/pleasure back due to my drastic reduction of porn use, and falling in love and getting married.

As I'm sure many of you know with EA. It's a bloody mystery! I've had it for so long, and tried so many different things, I gave up on it and rarely think about it anymore. So I hope the fibre does something and it can be replicated. But time will tell us if this is just another false hope.
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I'm Cured! / Re: Cured after 20 years of little or no pleassure from ejaculation
« Last post by Jonny on May 01, 2017, 04:38:05 AM »
What neuroleptic drug were you taking?

Quetiapine.
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What neuroleptic drug were you taking?
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General Discussion / Re: sexual anhedonia and anorgasmia from 5 days of celexa
« Last post by brunoital on April 22, 2017, 09:02:16 AM »
Check pm
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I'm Cured! / Re: Working out may cause lack of libido and/or orgasm
« Last post by gdop on April 20, 2017, 05:48:02 AM »
My problems started in my youth, when I didn't work out. I've never really worked out, only some soccer to have fun.
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I'm Cured! / Re: Cured after 20 years of little or no pleassure from ejaculation
« Last post by Jonny on April 17, 2017, 04:25:54 PM »
I have had EA for the last 3 years or so. It was caused by a neuroleptic. I first noticed a gradual decline in pleasure near the start of treatment, but thought I needed the drug, so kept on it for 6 years. I thought the sensation would come back when I came off it, but it didn't. I used to have full-body orgasms. Now I feel nothing except sometimes a faint bit of pleasure in my penis briefly when I ejaculate. Nothing in my head. I'm very bummed about this.

Tried gastrodin for 2 days, but it made me feel stressed and I found it hard to sleep. Guess it could be interacting with some other stuff I take. Oh well. Next on the list is ashwagandha.
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