General Category => Contributing Factors - Physical => Topic started by: no_longer_numb on May 12, 2018, 09:20:30 AM

Title: melanocortin, MSH, MC3R, phenylpropanalomine
Post by: no_longer_numb on May 12, 2018, 09:20:30 AM
Continuing to go down the rabbit hole...

If you remember my early posts I spoke about how I experienced changes in my libido/arousal/orgasm over time and at one time it was extremely HIGH.  I also noticed strange effects from cold medicines, possibly ones that contained an ingredient called phenylpropanalomine (PPA) which was subsequently banned in the USA and some other countries for stroke risk.

I was doing some other research and started reading about melanocortin or melanocyte stimulating hormone (MSH).  There is a company, Palatin that is working on approval for a drug that can treat EA in men and women.  One strange thing about all of this is this melanin stuff has to do with tanning etc, and I have periods where I suddenly become "tan" overnight and then it goes away, so clearly I have something going on with my melanin system etc.

It would appear that 23andme tests for a MC3R SNP https://www.snpedia.com/index.php/MC3R?

This website has phenylpropanalomine as the TOP GENE SUBSTANCE interaction with the MC3R gene:

This Palatin company also evidently works on a related compound for Inflammatory Bowel Disease, which I also have had in the past.

It seems there are tests for MSH:


Again, I need some help working this out from those with science/medical backgrounds or psychonauts out there, check out this guy's video: